It’s August and the activities keep coming. Those of us in the Tempe office managed to travel to cooler climates in July, and we have pictures to prove it below. This month’s events are mostly online. As always, check back to see if we have added anything. You can also see a list of events on our homepage and on the right column of the blog.
August 8-10: Austin, TX
2016 Annual International Solid Freeform Fabrication Symposium
This event is the academic side of 3D Printing. Less about the business and splash of the industry, this symposium focuses on R&D around the technology of freeform fabrication. PADT’s very own Dhruv Bhate will be there presenting a paper and interacting with other researchers in industry and academia.
August 15: Phoenix, AZ
AZ Additive Manufacturing Committee Meeting
Industrials leaders in 3D Printing across Arizona will be gathering for this month’s committee meeting at PADT. After the normal discussions, Dhruv Bhate will give a presentation then a tour of our 3D Printing resources.
We have several great Webinars on tap for August. All PADT webinars are recorded, so even if you can’t make the specified time register and we will send you a link to the recording.
Wednesday, August 10, 2016 – 12:00 PM AZ/PDT, 1:00 PM MDT
ANSYS AIM: Simulation For Product Design Engineers Register
Wednesday, August 24, 2016 – 12:00 PM AZ/PDT, 1:00 PM MDT
ANSYS AIM: Democratize Simulation for Your Design Engineers Register
Thursday, September 1, 2016 – 12:00 PM AZ/PDT, 1:00 PM MDT
ANSYS AIM: Increase Simulation Realism with Multiphysics
Watch this space for the date and registration link. Register
July Events in Review
Last month was all about 3D Printing, with a booth in Tucson and a road show to show off a brand new printer.
The ACTE AZ event in Tucson is always a fantastic chance for us to meet with our education customers and show educators why industrial quality systems are the right solution for classrooms and labs. The team had a great time… but didn’t send any pictures.
The “Full Color 3D Printer Road Show” was a big success. We started in Denver at a Brewery (we need to do this more often) with great presentations and a ton of sample parts that highlight the capability of the new Stratasys J750. We then moved the machines and parts on to Downtown Salt Lake City and where the interaction was fantastic amongst many veteran users. The final stop was in Scottsdale Arizona where we had our largest crowd and more great interaction.
The Denver event was on the local Money Talk radio station. You can listen to the interview here.
Not to be outdone, a local TV station covered the Arizona event. That clip can be found here.
Product design engineers are increasingly under pressure to complete product designs faster so innovative products can reach the market sooner. Performing up-front simulation as part of the product development process can accelerate designing optimized products and reduce costly physical prototypes. To successfully implement simulation early in the product development process, simulation software must be easy-to-use and cover all the necessary physics that impact product designs.
Join us for this webinar to discover how AIM delivers unparalleled ease-of-use for simulation driven product development, and learn how design engineers can benefit from using simulation early in the product development process.
This webinar will be held on August 10th from 1:00 pm – 2:00 pm PT
Is PolyJet MED610 truly biocompatible? And what does that mean anyway?
A couple of months ago, our product development team contacted me to see if I could 3D print them a small bio-compatible masking device that was needed for temporary attachment to an invasive device prior to insertion for surgery. That led me to investigate all the different bio-compatible materials we did have access to at PADT on our FDM (Fused Deposition Modeling) and PolyJet machines. Given the tiny size and high detail required in the part, I decided to opt for PolyJet, which does offer the MED610 material that is claimed to be biocompatible. As it so happens, we have an Objet Eden 260V PolyJet machine that has been dedicated to running MED610 exclusively since it’s installation a year ago.
We printed the mask, followed all the post-processing instructions per supplier recommendations (more on that later) and delivered the parts for further testing. And that is when I asked myself the questions at the top of this post.
I set off on a quest to see what I could find. My first stop was the RAPID conference in (May 2016), where the supplier (Stratasys Inc.) had a well-staffed booth – but no one there knew much about MED610 apart from the fact that some orthodontists were using it. I did pick up one interesting insight: one of the engineers there hypothesized that MED610 was not very popular because it was cost-prohibitive since its proper use required machine dedication. I then went to the Stratasys Direct Manufacturing (a service bureau owned by Stratasys) booth, but it turned out they don’t even offer MED610 as a material option for service jobs – presumably because of the low demand for this material, consistent with our own observations.
So I took a step back and began searching for all I could find in the public domain on MED610 – and while it wasn’t much, here is the summary of my findings that I hope help anyone interested in this. I categorize it in three sources of information: claims made by the supplier, published work on in vitro studies and finally, some in vivo animal trials. But first, we must ask…
What does it mean for a Material to be Biocompatible?
A definition by Williams (The Williams Dictionary of Biomaterials, 1999) is in order: “Biocompatibility is the ability of a material to perform with an appropriate host response in a specific application.” So if PolyJet MED610 is to be called biocompatible, we must ask – what application do we have in mind? Fortunately, the supplier has a recommendation.
MED610 was launched by Objet in 2011 (Objet was acquired by Stratasys in 2012) as a biocompatible material, ideal for “applications requiring prolonged skin contact of more than 30 days and short-term mucosal-membrane contact of up to 24 hours“. Stratasys claims that parts printed according to Objet MED610 Use and Maintenance Terms were evaluated for biocompatibility in accordance with standard “DIN EN ISO 10993-1: 2009, Biological Evaluation of Medical Devices-Part 1: Evaluation and testing within a risk management process. This addresses cytotoxicity, genotoxicity, delayed hypersensitivity, and USP plastic Class VI, which includes the test for irritation, acute systemic toxicity and implantation”. Unfortunately, the actual data from the biocompatibility study conducted by Objet have not been made publicly available.
It is important to remember that Stratasys publishes a “Use and Maintenance Terms” document that details the steps needed not just to clean the part after printing, but also on the proper setup of the machine for ensuring best chances of meeting biocompatibility requirements. These are published online at this link and include a 3 hour soak in a 1-percent NaOH solution, a 30 min soak in IPA and multiple water jet rinses, among other steps. In other words, the claimed biocompatibility of MED610 is only valid if these instructions are followed. These steps are primarily driven by the need to completely remove supports and any support-residue, but it is not clear if this is needed if a part can be printed without supports. Given such strong process dependencies, it is only to be expected that Stratasys provide a disclaimer at the end of the document clarifying that the users of their machines are responsible for independently validating biocompatibility of any device they make with MED610.
The next question is: have there been any relevant published, independent studies that have used MED610? In my search, I could only find two instances, which I discuss below.
Primary Human Cells Response (In Vitro)
In a recent (January 2016) study published in the Journal of Medical and Biological Engineering, Schmelzer et al. studied the response of primary human cells to four 3D printed materials in vitro: ABS, PC, PLA and MED610 – the only such study I could find. All samples instead went through a 100% ethanol brief rinse and were washed 5 times with de-mineralized water – this seems like a less stringent process than what the supplier recommends (3 hour 1-percent NaOH solution soak, 30 minutes IPA soak and 10 times waterjet blasting) but was designed to be identical across all the materials tested.
There were some very interesting findings:
Different cells had different responses:
MED610 had the most negative impact on cell viability for keratinocytes (epidermal cells that produce keratin) – and the only material that showed statistically significant difference from the control.
For bone marrow mesenchymal (stem) cells, a different effect was observed: direct culture on ABS and PC showed significant growth (7X compared to control) but MED610 and PLA showed no significant effect
Surface Roughness influences cell attachment and proliferation:
In agreement with other work, the authors showed that while rougher surfaces promote initial cell attachment, subsequent cell proliferation and overall cell numbers are higher on smoother surfaces. The MED610 samples had rougher surfaces than the FDM samples (possibly due to the use of the “matte” finish option) and could be one of the contributors to the observed negative effects on cell viability, along with the leached contents from the specimen.
Glaucoma Drainage Device (In Vivo, Rabbit studies)
The devices were printed on a Connex 350 PolyJet machine, after which the supports were removed from the devices with a water jet and “were repeatedly washed and inspected for consistency and integrity.” Tubes were attached with Silicone adhesive and the entire assembly was then “washed and sterilized with a hospital-grade hydrogen peroxide system before use”. The researchers did not examine the cellular and extracellular reactions in great detail, but did conclude that the reactions were similar between the MED610 device and the more standard polypropylene injection-molded device.
A short video recorded by some of the researchers as part of a Bioprinting course also provides some details into the 3D printing aspects of the work done.
In conclusion, the question I posed at the start of this post (Is PolyJet MED610 truly biocompatible?) is too simplistic. A process and a material together are not sufficient – there are procedures that need to be defined and controlled and further and more importantly, biocompatibility itself has to be viewed in the context of the application and the specific toxicity and interaction demands of that application. And that brings us to our key takeaways:
MED610 is only recommended at best for applications requiring prolonged skin contactof more than 30 days and short-term mucosal-membrane contact of up to 24 hours and there is no data to dispute the suppliers claim that it is biocompatible in this context once all recommended procedures are implemented
The work done by Australian researchers in using PolyJet MED610 for devoloping their Glaucoma Drainage Device in animal trials is perhaps the best example of how this material and the technology can be pushed further for evaluating designs and hypothesis in vivo when really fine features are needed. Stratasys’s FDM PC-ISO or ABS M30i materials, or other FDM extrusion capable materials like PLA, PCL and PLGA may be better options when the resolution allows – but this is a topic for a follow-on blog post.
More in vitro work needs to be done to extend the work done by Schmelzer et al., which suggests that MED610 potentially has leachables that do impact cell viability negatively. Specifically, effects of surface finish (“matte” vs “gloss”) and sterilization on cell viability is a worthwhile follow-on step. In the interim, MED610 is expected to perform well for mucosal membrane contact under 24 hours (and why this is a great technology for dental guides and other temporary in-mouth placement).
If you have any thoughts on this matter or would like to collaborate with us and take advantage of our access to a PolyJet printer that is dedicated to MED610 or other bio-compatible FDM materials, as well as our extensive post-processing and design & analysis facilities, please connect with me on LinkedIn or send us a note at email@example.com and cite this blog post.
Schmelzer, E., Over, P., Gridelli, B., & Gerlach, J. (2016). Response of Primary Human Bone Marrow Mesenchymal Stromal Cells and Dermal Keratinocytes to Thermal Printer Materials In Vitro. Journal of Medical and Biological Engineering, 36, 153-167.
Ross C, Pandav S, Li Y, et al. Determination of Bleb Capsule Porosity With an Experimental Glaucoma Drainage Device and Measurement System. JAMA Ophthalmol.2015;133(5):549-554. doi:10.1001/jamaophthalmol.2015.30.
Our loop around the Southwest with the new Stratasys J750 Full Color 3D Printer finished strong with a well attended gathering at ASU’s Skysong in Scottsdale. The event was so popular, Channel 10 did a story on it. Over 130 people signed up to learn more about this fantastic device, get caught up on latest industry trends, and talk with other users of Additive Manufacturing.
This event had a great mix of users from multiple industries as well as students and people wanting to just learn more about the technology.
The presentations were a big hit from every seminar, and Dhruv’s was especially popular in Arizona. You can download the presentations here:
During the breaks and after the presentations, we had a chance to interact one-on-one with customers, show off parts, and answer questions. If you have any questions, please feel free to contact us at 480.813.4884 or firstname.lastname@example.org.
Lastly, we were visited by local TV channel 10, KSAZ who did a short but really informative segment on the show and the Stratasys J750:
The second stop on our trip around the Southwest for Stratasys’ new J750 Full Color 3D Printer was in fantastic downtown Salt Lake City. This device is reinventing 3D printing, and we are showing it off in person so people can see it up close along with holding incredible parts it makes in their hands.
The 3D Printing community in Utah is very mature and the attendees were mostly very experienced users of many different additive manufacturing technologies. So we focused on real world applications for the J750 as well as other Stratasys systems.
We were fortunate enought to have a customer, Ultradent, present the fantastic ways that they use their FDM and Polyjet printers to make prototypes, tooling, and production parts.
As is usual in this type of an event, the discussion between and after presentations are the best part. People from Aerospace, sporting goods, medical devices, and consumer products swapped stories, suggestions, and tips.
It was also a family affair. with Jame Barker’s latest family addition was in attendence to help spread the word on the value of 3D Printing with Stratasys solutions:Beyond the little guy, the other hit of the afternoon was the J750. As seasoned additive manufacturing profesionals they see the incredible leap forward this machine represents – truly reinventing 3D Printing and opening up a huge range of oportunities.
As engineers, we struggle with using social networks to market our company. Engineers are not as in to social networking and they are adverse to anything that looks like a sale. “The five C’s of effective social network marketing” goes over some of the things that have worked for PADT and should help similar tech companies get greater value – Clear Messaging, Consistency, Content, Conciseness, and Cross Platform.
Denver was the first stop on a trip around the Southwest for Stratasys’ new J750 Full Color 3D Printer. We are showing this machine that is reinventing 3D printing off in person so people can see the device up close and hold the incredible parts it makes in their hands.
The Denver event was hosted by St. Patrick’s Brewery in Littleton, right down the street from PADT’s Colorado Office. Several customers and PADT employees gave talks on how to better use 3D Printing, including a presentation from Mario Vargas on the new Stratasys J750.
On top of all of that, local radio station KDMT, Denver’s Money Talk 1690, did a live broadcast from the event. You can listen in here. Again, PADT employees and customers talked about 3D Printing as well as the new Stratasys J750.
We also made the local paper, check that out here.
We are pleased to announce that PADT has been awarded a grant from America Makes to further our research into combining our three favorite things: Simulation, 3D Printing, and Product Development. We will work with our partners at ASU, Honeywell Aerospace, and LAI International to study lattice structures created in 3D Printing, how to model them in ANSYS simulation software, and then how to use that information to drive product design.
A copy of the press release is below. Or read the official press release or download a PDF .
Innovative Additive Manufacturing Research Project Led by PADT Approved as Part of America Makes Multi-Million Dollar Grants
Arizona State University, Honeywell Aerospace and LAI International join PADT in technical research and educational outreach in 3D Printing
TEMPE, Ariz., July 25, 2016 — In one of the most critically needed areas of research in Additive Manufacturing, Phoenix Analysis & Design Technologies (PADT), the Southwest’s largest provider of numerical simulation, product development and 3D Printing services and products, today announced its project proposal titled “A Non-Empirical Predictive Model for Additively Manufactured Lattice Structures,” has been accepted as part of a multi-million dollar grant from the National Additive Manufacturing Innovation Institute, America Makes. PADT’s proposal was one of only seven selected, and one of only two where the leading organization was a small business.
To complete the deliverables, Arizona State University (ASU), Honeywell Aerospace and LAI International are assisting PADT in technical research with contributions from Prof. Howard Kuhn, a Professor at the University of Pittsburgh and a leading educator in Additive Manufacturing, for workforce and educational outreach.
“While there are several efforts ongoing in developing design and optimization software for lattice structures in additive manufacturing, there has been little progress in developing a robust, validated material model that accurately describes how these structures behave,” said Dhruv Bhate, PhD, senior technologist, PADT and author and principal investigator of the proposal. “We are honored to be chosen to research this important issue and provide the tools to enable entrepreneurs, manufacturers and makers to integrate lattice structures in their designs.”
One of the most definitive benefits of additive manufacturing is the ability to reduce weight while maintaining mechanical performance. A way to achieve this is by adding lattice structures to parts before manufacturing. The advantages are crucial and can result in increased design flexibility, lower material costs and significant reductions in production time for industries such as aerospace and automotive.
Another aspect of PADT’s winning proposal is the development of a first-of-a-kind online, collaborative living textbook on Additive Manufacturing that seeks to provide comprehensive, up-to-date and structured information in a field where over 50 papers are published worldwide every day. In addition, the team will develop a training class that addresses manufacturing, testing, theory and simulation as well as how they are combined together to deliver robust predictions of lattice behavior.
“We have identified Additive Manufacturing as a key lever of innovation in our company and recognize lattice structures as an important design capability to reduce mass, improve performance and reduce costs,” said Suraj Rawal, Technical Fellow, Advanced Technology Center at Lockheed Martin Space Systems Company – a leader in implementing Additive Manufacturing. “We also recognize the significance of this work in lattice behavior modeling and prediction as an important contribution to help implement the design, manufacturing, and performance validation of structures in our innovative designs.”
The award of this grant is another example of the leadership role that Arizona is playing in advancing the practical application of Additive Manufacturing, better known as 3D Printing. PADT’s leadership role in the Arizona Technology Council’s Arizona Additive Manufacturing Committee, support of basic research in the area at ASU, and involvement with educating the next generation of users underscores PADT’s contribution to this effort and furthers the company’s commitment to “Make Innovation Work.”
About Phoenix Analysis and Design Technologies
Phoenix Analysis and Design Technologies, Inc. (PADT) is an engineering product and services company that focuses on helping customers who develop physical products by providing Numerical Simulation, Product Development, and Rapid Prototyping solutions. PADT’s worldwide reputation for technical excellence and experienced staff is based on its proven record of building long term win-win partnerships with vendors and customers. Since its establishment in 1994, companies have relied on PADT because “We Make Innovation Work.” With over 80 employees, PADT services customers from its headquarters at the Arizona State University Research Park in Tempe, Arizona, and from offices in Torrance, California, Littleton, Colorado, Albuquerque, New Mexico, and Murray, Utah, as well as through staff members located around the country. More information on PADT can be found at http://www.PADTINC.com.
If you have used or are using CFD tools like ANSYS Fluent or ANSYS CFX, then you already know how much of a pain extracting the fluid volume can be from a CAD model. Whether the extraction fails because of geometry issues, or if you’ve forgotten to create capping surfaces for all your openings it can be quite frustrating when you get the “non-manifold body” error.
We’ve done it the same way for a long time – create some super solid and do a Boolean subtract or try to close everything off and try to use a cavity function to fill in the model. Both can have headache inducing issues.
CLICK HERE for a PDF that shows how ANSYS SpaceClaim uses a different approach which can make the fluid volume extraction much easier for engineers.
If you have visited PADT’s headquarters in Tempe, Arizona you know that we have been next to an empty lot since we moved in. Today our new neighbors, Arizona Oncology, broke ground on their new East Valley facility. Although we will miss watching the bunny rabbits and the unobstructed view of Elliot Road, we are happy to have a nice looking facility next door.
During the groundbreaking ceremonies we learned that they are the largest Oncology treatment provider in the valley. I also learned that other recent additions to the ASU Research Park bring the total of employees in the park to 6000. The addition of Arizona Oncology’s 21,000 sq ft facility will add even more and will be a center for their research and clinical trials as well as a fully integrated care facility.
PCB designers know that it is critical to design a board for temperature rise, thermal expansion and external structural loads. The difficulty has always been to capture a board’s structural makeup accurately without having an impractical effect on solve time.
CLICK HERE for a PDF that shows how ANSYS solves this challenge in a unique straightforward and effective manner. And as always feel free to reach out to us at email@example.com if you have any questions.
We have all experienced times where someone uses regulations and rules as an excuse to stop or slow some initiative in a company. The blog post “Why it’s time to stop using regulations as an excuse” is a bit of a rant on why this is a bad idea and what we can do to avoid it.
A successful startup is often the result of how the leadership performs. In most cases the ideal CEO doesn’t exist, and if you dig down you usually find that the company is being led by two people who compliment each other. In “For every Woz, you need a Jobs” I look at one of the most famous, and successful such partnering and share some other examples and how to recognize and promote the ideal pairing.